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Yuzu extract prevents cognitive decline and impaired glucose homeostasis in β-amyloid-infused rats.
- Source :
-
The Journal of nutrition [J Nutr] 2013 Jul; Vol. 143 (7), pp. 1093-9. Date of Electronic Publication: 2013 May 29. - Publication Year :
- 2013
-
Abstract
- Our preliminary study revealed that dementia induced by β-amyloid accumulation impairs peripheral glucose homeostasis (unpublished). We therefore evaluated whether long-term oral consumption of yuzu (Citrus junos Tanaka) extract improves cognitive dysfunction and glucose homeostasis in β-amyloid-induced rats. Male rats received hippocampal CA1 infusions of β-amyloid (25-35) [plaque forming β-amyloid; Alzheimer disease (AD)] or β-amyloid (35-25) [non-plaque forming β-amyloid; C (non-Alzheimer disease control)] at a rate of 3.6 nmol/d for 14 d. AD rats were divided into 2 dietary groups that received either 3% lyophilized 70% ethanol extracts of yuzu (AD-Y) or 3% dextrin (AD-C) in high-fat diets (43% energy as fat). The AD-C group exhibited greater hippocampal β-amyloid deposition, which was not detected in the C group, and attenuated hippocampal insulin signaling. Yuzu treatment prevented β-amyloid accumulation, increased tau phosphorylation, and attenuated hippocampal insulin signaling observed in AD-C rats. Consistent with β-amyloid accumulation, the AD-C rats experienced cognitive dysfunction, which was prevented by yuzu. AD-C rats gained less weight than did C rats due to decreased feed consumption, and yuzu treatment prevented the decrease in feed consumption. Serum glucose concentrations were higher in AD-C than in C rats at 40-120 min after glucose loading during an oral-glucose-tolerance test, but not at 0-40 min. Serum insulin concentrations were highly elevated in AD-C rats but not enough to lower serum glucose to normal concentrations, indicating that rats in the AD-C group had insulin resistance and a borderline diabetic state. Although AD-C rats were profoundly insulin resistant, AD-Y rats exhibited normal first and second phases of glucose tolerance and insulin sensitivity and secretion. In conclusion, yuzu treatment prevented the cognitive dysfunction and impaired energy and glucose homeostasis induced by β-amyloid infusion.
- Subjects :
- Administration, Oral
Alzheimer Disease drug therapy
Alzheimer Disease prevention & control
Animals
Blood Glucose analysis
CA1 Region, Hippocampal drug effects
CA1 Region, Hippocampal metabolism
Cognition Disorders prevention & control
Diet, High-Fat
Flavonoids administration & dosage
Flavonoids analysis
Glucose Tolerance Test
Insulin blood
Insulin Resistance
Male
Phenols administration & dosage
Phenols analysis
Rats
Rats, Sprague-Dawley
Signal Transduction
Amyloid beta-Peptides administration & dosage
Amyloid beta-Peptides adverse effects
Citrus chemistry
Cognition Disorders drug therapy
Homeostasis drug effects
Peptide Fragments administration & dosage
Peptide Fragments adverse effects
Plant Extracts administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1541-6100
- Volume :
- 143
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The Journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 23719224
- Full Text :
- https://doi.org/10.3945/jn.112.173401