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Sorafenib: from literature to clinical practice.
- Source :
-
Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2013 Apr; Vol. 24 Suppl 2, pp. ii30-7. - Publication Year :
- 2013
-
Abstract
- Sorafenib is considered the standard systemic therapy for hepatocellular carcinoma (HCC), in patients with well-preserved liver function (Child-Pugh A class) and advanced-stage HCC (BCLC-C) or in patients with HCC progressing after locoregional therapies, with a high grade of recommendation. The approval of sorafenib for this indication was grounded on the efficacy and the safety results reported by two international randomized, controlled trials, the SHARP and the Asia-Pacific studies. In addition, the efficacy and the safety of sorafenib in clinical practice are addressed by several field-practice experiences, including the multinational GIDEON study and the SOFIA study. Finally, further research on sorafenib is ongoing to optimize the use of this molecule. This review aims to provide an overview of the most relevant clinical data on the efficacy and the safety of sorafenib in patients with HCC.
- Subjects :
- Animals
Carcinoma, Hepatocellular enzymology
Carcinoma, Hepatocellular mortality
Carcinoma, Hepatocellular pathology
Evidence-Based Medicine
Humans
Liver Neoplasms enzymology
Liver Neoplasms mortality
Liver Neoplasms pathology
Neoplasm Staging
Niacinamide adverse effects
Niacinamide therapeutic use
Phenylurea Compounds adverse effects
Randomized Controlled Trials as Topic
Risk Factors
Sorafenib
Time Factors
Treatment Outcome
Antineoplastic Agents therapeutic use
Carcinoma, Hepatocellular drug therapy
Liver Neoplasms drug therapy
Molecular Targeted Therapy
Niacinamide analogs & derivatives
Phenylurea Compounds therapeutic use
Protein Kinase Inhibitors therapeutic use
Translational Research, Biomedical
Subjects
Details
- Language :
- English
- ISSN :
- 1569-8041
- Volume :
- 24 Suppl 2
- Database :
- MEDLINE
- Journal :
- Annals of oncology : official journal of the European Society for Medical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 23715941
- Full Text :
- https://doi.org/10.1093/annonc/mdt055