Synthesis of an (11) C-labeled antiprion GN8 derivative and evaluation of its brain uptake by positron emission tomography.

Authors :: Kimura T
Sako T
Siqin
Hosokawa-Muto J
Cui YL
Wada Y
Kataoka Y
Doi H
Sakaguchi S
Suzuki M
Watanabe Y
Kuwata K
Source :: ChemMedChem [ChemMedChem] 2013 Jul; Vol. 8 (7), pp. 1035-9. Date of Electronic Publication: 2013 May 24.
Publication Year :: 2013
Abstract: A radiolabeled PET! A (11) C-labeled derivative of N,N'-(methylenedi-4,1-phenylene)bis[2-(1-pyrrolidinyl) acetamide] (GN8), an antiprion agent currently under development, was synthesized by palladium-catalyzed rapid methylation of aryltributylstannane and assessed for brain penetration and organ distribution in rats by positron emission tomography (PET).<br /> (Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Acetamides pharmacology
Animals
Brain diagnostic imaging
Brain pathology
Carbon Radioisotopes
Humans
Molecular Structure
Tissue Distribution
Acetamides chemical synthesis
Acetamides pharmacokinetics
Brain metabolism
Positron-Emission Tomography
Prions antagonists & inhibitors

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