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Engineering polymeric microparticles as theranostic carriers for selective delivery and cancer therapy.
- Source :
-
Advanced healthcare materials [Adv Healthc Mater] 2013 Dec; Vol. 2 (12), pp. 1571-5. Date of Electronic Publication: 2013 May 28. - Publication Year :
- 2013
-
Abstract
- Multifunctional polymeric nano- and microparticles are engineered as theranostic carriers and their selective size-dependent cellular uptake is demonstrated. It is found that effective uptake and accumulation of nanoparticles occurs in both normal and cancer cells, whereas, that of microparticles occurs in cancer cells but not in normal cells, allowing cancer cells to be specifically targeted for local drug delivery.<br /> (Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Antineoplastic Agents pharmacokinetics
Antineoplastic Agents pharmacology
Camptothecin chemistry
Camptothecin pharmacokinetics
Camptothecin pharmacology
Cell Line
Cell Line, Tumor
Cell Survival drug effects
Drug Carriers pharmacokinetics
Drug Carriers pharmacology
Humans
Lactic Acid pharmacokinetics
Lactic Acid pharmacology
Microspheres
Nanoparticles chemistry
Polyglycolic Acid pharmacokinetics
Polyglycolic Acid pharmacology
Polylactic Acid-Polyglycolic Acid Copolymer
Antineoplastic Agents chemistry
Drug Carriers chemistry
Lactic Acid chemistry
Polyglycolic Acid chemistry
Quantum Dots
Subjects
Details
- Language :
- English
- ISSN :
- 2192-2659
- Volume :
- 2
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Advanced healthcare materials
- Publication Type :
- Academic Journal
- Accession number :
- 23712912
- Full Text :
- https://doi.org/10.1002/adhm.201300077