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Tacrolimus plus mycophenolate mofetil vs. cyclosporine plus everolimus in deceased donor kidney transplant recipients: three-yr results of a single-center prospective clinical trial.
- Source :
-
Clinical transplantation [Clin Transplant] 2013 Jul-Aug; Vol. 27 (4), pp. E359-67. Date of Electronic Publication: 2013 May 26. - Publication Year :
- 2013
-
Abstract
- We compared in kidney transplantation two immunosuppressive regimens: tacrolimus plus mycophenolate mofetil (MMF) (TAC) and everolimus plus low-dose cyclosporine (EVE). Sixty consecutive patients received TAC (30 patients) or EVE (30 patients) as immunosuppressive regimen; all subjects also received induction with basiliximab and corticosteroids. After three-yr follow-up, no difference was found in patient and graft survival (PTS: TAC: 97% vs. EVE: 100%; GS: TAC: 93% vs. EVE: 93%). The incidence of acute rejection was higher in the EVE group but the difference was not statistically significant (17% vs. 23%, p = ns). Patients in EVE showed higher serum cholesterol (205 ± 41 vs. 235 ± 41 mg/dL, p = 0.0012) and lower hemoglobin concentration (13.6 ± 1.4 vs. 12.4 ± 1.9, p = 0.01). Renal function was not significantly different in the two groups (3 Y creatinine: TAC 1.4 ± 0.8 vs. EVE 1.6 ± 0.8 mg/dL, p = ns). Treatment discontinuation was higher in the EVE group (TAC 17 vs. EVE 36%, p = ns). Our data show that in the middle-term follow-up, an immunosuppressive regimen with tacrolimus plus MMF has a similar efficacy and safety profile in comparison with the combination of low-exposure cyclosporine plus everolimus. Further follow up could evidence the benefits related to the anti-proliferative effects of everolimus.<br /> (© 2013 John Wiley & Sons A/S.)
- Subjects :
- Adult
Case-Control Studies
Cyclosporine therapeutic use
Delayed Graft Function
Drug Therapy, Combination
Dyslipidemias diagnosis
Dyslipidemias drug therapy
Dyslipidemias etiology
Everolimus
Female
Follow-Up Studies
Glomerular Filtration Rate
Graft Rejection diagnosis
Graft Rejection etiology
Graft Survival
Humans
Kidney Failure, Chronic surgery
Kidney Function Tests
Male
Middle Aged
Mycophenolic Acid analogs & derivatives
Mycophenolic Acid therapeutic use
Prognosis
Prospective Studies
Risk Factors
Sirolimus analogs & derivatives
Sirolimus therapeutic use
Survival Rate
Tacrolimus therapeutic use
Tissue Donors
Young Adult
Graft Rejection drug therapy
Immunosuppressive Agents therapeutic use
Kidney Failure, Chronic complications
Kidney Transplantation adverse effects
Postoperative Complications
Subjects
Details
- Language :
- English
- ISSN :
- 1399-0012
- Volume :
- 27
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Clinical transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 23710603
- Full Text :
- https://doi.org/10.1111/ctr.12141