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Dietary sesame seed and its lignan, sesamin, increase tocopherol and phylloquinone concentrations in male rats.
- Source :
-
The Journal of nutrition [J Nutr] 2013 Jul; Vol. 143 (7), pp. 1067-73. Date of Electronic Publication: 2013 May 22. - Publication Year :
- 2013
-
Abstract
- We have shown that intake of sesame seed and its lignan increases vitamin E concentrations and decreases urinary excretion levels of vitamin E metabolites in male Wistar rats, suggesting inhibition of vitamin E catabolism by sesame lignan. The aim of this study was to examine whether dietary sesame seed also increased vitamin K concentrations, because its metabolic pathway is similar to that of vitamin E. To test the effect of sesame lignan on vitamin K concentrations, male Wistar rats were fed a control diet or a diet with 0.2% sesamin (a sesame lignan) for 7 d in experiment 1. Liver phylloquinone (PK), menaquinone-4 (MK-4), and γ-tocopherol were greater in rats fed sesamin than in control rats. To test the effect of sesame seed on vitamin K concentrations, male Wistar rats were fed a control diet or a diet with 1, 5, or 10% sesame seed for 3 d in experiment 2. Liver and kidney PK and γ-tocopherol but not MK-4 were greater in rats fed sesame seed than in control rats, although differences in dietary amounts of sesame seed did not affect the PK concentrations. For further confirmation of the effect of sesame seed, male Wistar rats were fed a control diet or a diet with 20% sesame seed for 40 d in experiment 3. Kidney, heart, lung, testis, and brain PK and brain MK-4 were greater in rats fed sesame seed than in control rats. The present study revealed for the first time, to our knowledge, that dietary sesame seed and sesame lignan increase not only vitamin E but also vitamin K concentrations in rat tissues.
- Subjects :
- Animals
Brain drug effects
Brain metabolism
Dioxoles chemistry
Heart drug effects
Kidney drug effects
Kidney metabolism
Lignans chemistry
Liver drug effects
Liver metabolism
Lung drug effects
Lung metabolism
Male
Rats
Rats, Wistar
Seeds chemistry
Testis drug effects
Testis metabolism
Vitamin K 1 metabolism
Vitamin K 2 analogs & derivatives
Vitamin K 2 analysis
Vitamin K 2 metabolism
gamma-Tocopherol metabolism
Diet
Dioxoles administration & dosage
Lignans administration & dosage
Sesamum chemistry
Vitamin K 1 analysis
gamma-Tocopherol analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1541-6100
- Volume :
- 143
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The Journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 23700348
- Full Text :
- https://doi.org/10.3945/jn.113.176636