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[Molecular genetic detection of minimal residual disease (MRD) in children with acute lymphoblastic leukemia].
- Source :
-
Klinische Padiatrie [Klin Padiatr] 2013 May; Vol. 225 Suppl 1, pp. S40-4. Date of Electronic Publication: 2013 May 22. - Publication Year :
- 2013
-
Abstract
- The treatment of acute lymphoblastic leukemia (ALL) in childhood and adolescence achieves nowadays cure rates of more than 80%. The detection of minimal residual disease (MRD) via molecular genetic methods provides - in comparison with conventional clinical and biological parameters - much more sensitive approaches to monitor individual treatment response. Here we will discuss the molecular background and technical developments in the framework of the BFM-study group.<br /> (© Georg Thieme Verlag KG Stuttgart · New York.)
- Subjects :
- Antineoplastic Combined Chemotherapy Protocols adverse effects
Asparaginase adverse effects
Asparaginase therapeutic use
Child
Cyclophosphamide adverse effects
Cyclophosphamide therapeutic use
Cytarabine adverse effects
Cytarabine therapeutic use
Daunorubicin adverse effects
Daunorubicin therapeutic use
Genetic Markers genetics
Humans
Mercaptopurine adverse effects
Mercaptopurine therapeutic use
Methotrexate adverse effects
Methotrexate therapeutic use
Neoplasm, Residual classification
Neoplasm, Residual drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma classification
Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy
Prednisone adverse effects
Prednisone therapeutic use
Prognosis
Prospective Studies
Vincristine adverse effects
Vincristine therapeutic use
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Neoplasm, Residual diagnosis
Neoplasm, Residual genetics
Polymerase Chain Reaction
Precursor Cell Lymphoblastic Leukemia-Lymphoma diagnosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma genetics
Subjects
Details
- Language :
- German
- ISSN :
- 1439-3824
- Volume :
- 225 Suppl 1
- Database :
- MEDLINE
- Journal :
- Klinische Padiatrie
- Publication Type :
- Academic Journal
- Accession number :
- 23700054
- Full Text :
- https://doi.org/10.1055/s-0033-1337962