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The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation.
- Source :
-
The Journal of investigative dermatology [J Invest Dermatol] 2013 Dec; Vol. 133 (12), pp. 2714-2721. Date of Electronic Publication: 2013 May 22. - Publication Year :
- 2013
-
Abstract
- Evidence is accumulating to suggest that our indigenous microbial communities (microbiota) may have a role in modulating allergic and immune disorders of the skin. To examine the link between the microbiota and atopic dermatitis (AD), we examined a mouse model of defective cutaneous barrier function with an AD-like disease due to loss of Notch signaling. Comparisons of conventionally raised and germ-free (GF) mice revealed a similar degree of allergic skin inflammation, systemic atopy, and airway hypersensitivity. GF mutant animals expressed significantly higher levels of thymic stromal lymphopoietin, a major proinflammatory cytokine released by skin with defective barrier function, resulting in a more severe B-lymphoproliferative disorder that persisted into adulthood. These findings suggest a role for the microbiota in ameliorating stress signals released by keratinocytes in response to perturbation in cutaneous barrier function.
- Subjects :
- Alleles
Animals
Female
Genotype
Immunoglobulin E blood
Immunoglobulin J Recombination Signal Sequence-Binding Protein genetics
Keratinocytes cytology
Male
Mice
Mice, Knockout
Microbiota
Thymic Stromal Lymphopoietin
Cytokines metabolism
Gene Expression Regulation
Hypersensitivity metabolism
Inflammation metabolism
Skin immunology
Skin microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1523-1747
- Volume :
- 133
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The Journal of investigative dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 23698100
- Full Text :
- https://doi.org/10.1038/jid.2013.228