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Antigens of the major histocompatibility complex in patients with chronic discoid lupus erythematosus.
- Source :
-
The British journal of dermatology [Br J Dermatol] 1990 Jun; Vol. 122 (6), pp. 723-8. - Publication Year :
- 1990
-
Abstract
- The frequencies of the major histocompatibility complex class I, class II and class III antigens were determined in 130 patients (88 women and 42 men) with chronic discoid lupus erythematosus, and compared with those of 764 healthy controls. A significant increase in HLA-B7 (38.0% in the patients vs. 25.8% in the control group), HLA-B8 (29.5% vs. 17.4%), HLA-Cw7 (58.9% vs. 26.1%), HLA-DR2 (46.9% vs. 29.7%), HLA-DR3 (32.0% vs. 19.4%), HLA-DQw1 (76.6% vs. 60.5%), and a decrease in HLA-A2 (41.9% vs. 55.7%) was found. The calculated relative risk values for the respective antigens markedly increased when two or more antigens were present in one patient, with a maximum relative risk value of 7.4 for the combinations of HLA-Cw7, DR3, DQw1 and HLA-B7, Cw7 and DR3, which were found in 17.2% of the patients and in only 2.3% of the controls.
- Subjects :
- Chronic Disease
Disease Susceptibility
Female
HLA-A2 Antigen analysis
HLA-B7 Antigen analysis
HLA-B8 Antigen analysis
HLA-C Antigens analysis
HLA-DQ Antigens analysis
HLA-DR2 Antigen analysis
HLA-DR3 Antigen analysis
Humans
Male
Risk
HLA Antigens analysis
Lupus Erythematosus, Discoid immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0007-0963
- Volume :
- 122
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The British journal of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 2369554
- Full Text :
- https://doi.org/10.1111/j.1365-2133.1990.tb06258.x