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Clinical outcomes in patients with stage I non-seminomatous germ cell cancer.
Clinical outcomes in patients with stage I non-seminomatous germ cell cancer.
- Source :
-
Asian journal of andrology [Asian J Androl] 2013 Jul; Vol. 15 (4), pp. 558-63. Date of Electronic Publication: 2013 May 20. - Publication Year :
- 2013
-
Abstract
- This study assesses the long-term outcomes in Han Chinese patients with clinical stage I non-seminomatous germ cell testicular cancer (CSI NSGCT) treated with surveillance, retroperitoneal lymph node dissection (RPLND) and adjuvant chemotherapy. We retrospectively evaluated 89 patients with a mean age of 26.5 years. After orchiectomy, 37 patients were treated with surveillance, 34 underwent RPLND and 18 were managed with chemotherapy. The overall survival rate, the recurrence-free survival rate and the risk factors were evaluated. The median follow-up length was 92 months (range: 6-149 months). Thirteen of the 89 patients (14.6%) had relapses, and one died by the evaluation date. The overall survival rate was 98.9%. The cumulative 4-year recurrence-free rates were 80.2%, 92.0% and 100% for the surveillance, RPLND and chemotherapy groups, respectively. The disease-free period tended to be briefer in patients with a history of cryptorchidism and those with stage Is. Therefore, surveillance, RPLND and adjuvant chemotherapy might be reliable strategies in compliant patients with CSI NSGCT. Surveillance should be recommended for patients with the lowest recurrence rate, especially those without lymphovascular invasion. This study might aid the establishment of a standard therapy for CSI NSGCT in China.
- Subjects :
- Adolescent
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Bleomycin therapeutic use
Child
Child, Preschool
China epidemiology
Cisplatin therapeutic use
Disease-Free Survival
Etoposide therapeutic use
Follow-Up Studies
Humans
Infant
Lymph Node Excision
Male
Middle Aged
Neoplasm Recurrence, Local mortality
Neoplasm Recurrence, Local pathology
Neoplasm Staging
Neoplasms, Germ Cell and Embryonal drug therapy
Neoplasms, Germ Cell and Embryonal surgery
Orchiectomy
Retrospective Studies
Risk Factors
Testicular Neoplasms drug therapy
Testicular Neoplasms surgery
Treatment Outcome
Young Adult
Neoplasms, Germ Cell and Embryonal mortality
Neoplasms, Germ Cell and Embryonal pathology
Testicular Neoplasms mortality
Testicular Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1745-7262
- Volume :
- 15
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Asian journal of andrology
- Publication Type :
- Academic Journal
- Accession number :
- 23685909
- Full Text :
- https://doi.org/10.1038/aja.2013.16