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Viruses and antiviral immunity in Drosophila.
- Source :
-
Developmental and comparative immunology [Dev Comp Immunol] 2014 Jan; Vol. 42 (1), pp. 67-84. Date of Electronic Publication: 2013 May 13. - Publication Year :
- 2014
-
Abstract
- Viral pathogens present many challenges to organisms, driving the evolution of a myriad of antiviral strategies to combat infections. A wide variety of viruses infect invertebrates, including both natural pathogens that are insect-restricted, and viruses that are transmitted to vertebrates. Studies using the powerful tools in the model organism Drosophila have expanded our understanding of antiviral defenses against diverse viruses. In this review, we will cover three major areas. First, we will describe the tools used to study viruses in Drosophila. Second, we will survey the major viruses that have been studied in Drosophila. And lastly, we will discuss the well-characterized mechanisms that are active against these diverse pathogens, focusing on non-RNAi mediated antiviral mechanisms. Antiviral RNAi is discussed in another paper in this issue.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Antigens, Viral immunology
Drosophila Proteins immunology
Drosophila melanogaster virology
Gene Expression Profiling
Host-Pathogen Interactions
Humans
Immunity
Models, Animal
RNA Interference immunology
Signal Transduction
Toll-Like Receptors immunology
Arboviruses immunology
Drosophila Proteins metabolism
Drosophila melanogaster immunology
Picornaviridae immunology
Toll-Like Receptors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0089
- Volume :
- 42
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Developmental and comparative immunology
- Publication Type :
- Academic Journal
- Accession number :
- 23680639
- Full Text :
- https://doi.org/10.1016/j.dci.2013.05.002