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[A new physiopathological classification of diabetic neuropathy].

Authors :
Olmos PR
Niklitschek S
Olmos RI
Faúndez JI
Quezada TA
Bozinovic MA
Niklitschek IA
Acosta J
Valencia CN
Bravo FA
Source :
Revista medica de Chile [Rev Med Chil] 2012 Dec; Vol. 140 (12), pp. 1593-605.
Publication Year :
2012

Abstract

Nowadays, Diabetic Neuropathy (DN) is considered the most common cause of peripheral neuropathy in clinical practice. It can affect sensitive, motor or autonomic nerve fibers, with symmetric, asymmetric, acute or chronic presentations. Due to this variability, with multiple physiopathologic mechanisms involved, a complex clinical classification has been used until recently. The aim of this review is to present a new classification of diabetic neuropathy, based on its physiopathology. It is divided in metabolic microvascular and hypoxic, autoimmune and inflammatory, compressive, secondary to complications of diabetes and related to treatment. It must be understood that DN is not just a functional disease, but a complication of diabetes with molecular and pathological substrates caused by hyperglycemia. Therefore, normalization of blood glucose is a fundamental step towards the successful prevention and treatment of DN.

Details

Language :
Spanish; Castilian
ISSN :
0717-6163
Volume :
140
Issue :
12
Database :
MEDLINE
Journal :
Revista medica de Chile
Publication Type :
Academic Journal
Accession number :
23677234
Full Text :
https://doi.org/10.4067/S0034-98872012001200012