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Quality of harvest and role of cell dose in unrelated bone marrow transplantation: an Italian Bone Marrow Donor Registry-Gruppo Italiano Trapianto di Midollo Osseo Study.
- Source :
-
Hematology (Amsterdam, Netherlands) [Hematology] 2014 Jan; Vol. 19 (1), pp. 1-9. Date of Electronic Publication: 2013 Nov 25. - Publication Year :
- 2014
-
Abstract
- In this study, we investigated the factors affecting cell dose harvest and the role of cell dose on outcome. We analysed data from a cohort of 703 patients who underwent unrelated bone marrow transplantation facilitated by IBMDR in GITMO centers between 2002 and 2008. The median-infused cell doses is 3.7 × 10(8)/kg, the correlation between the nucleated cells requested from transplant centers and those harvested by collection centers was adequate. A harvested/requested cells ratio lower than 0.5 was observed only in 3% of harvests. A volume of harvested marrow higher than the median value of 1270 ml was related to a significant lower infused cell dose (χ(2): 44.4; P < 0.001). No patient- or donor-related variables significantly influenced the cell dose except for the recipient younger age (χ(2): 95.7; P < 0.001) and non-malignant diseases (χ(2): 33.8; P < 0.001). The cell dose resulted an independent predictor factor for a better outcome in patients affected by non-malignant disease (P = 0.05) while early disease malignant patients receiving a lower cell dose showed a higher risk of relapse (P = 0.05).
- Subjects :
- Adolescent
Adult
Bone Marrow Transplantation adverse effects
Child
Child, Preschool
Female
Humans
Infant
Infant, Newborn
Italy
Male
Middle Aged
Recurrence
Tissue and Organ Harvesting standards
Transplantation Conditioning adverse effects
Transplantation Conditioning methods
Transplantation, Homologous
Treatment Outcome
Young Adult
Bone Marrow Transplantation methods
Tissue and Organ Harvesting methods
Unrelated Donors
Subjects
Details
- Language :
- English
- ISSN :
- 1607-8454
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Hematology (Amsterdam, Netherlands)
- Publication Type :
- Academic Journal
- Accession number :
- 23677141
- Full Text :
- https://doi.org/10.1179/1607845413Y.0000000086