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Triterpenoid saponins with anti-myocardial ischemia activity from the whole plants of Clematis tangutica.
- Source :
-
Planta medica [Planta Med] 2013 May; Vol. 79 (8), pp. 673-9. Date of Electronic Publication: 2013 May 13. - Publication Year :
- 2013
-
Abstract
- Four new triterpenoid saponins named clematangosides A-D (1-4) along with six known saponins (5-10) were isolated from the whole plants of Clematis tangutica. Their structures were determined by extensive spectral analysis and chemical evidences. All saponins were evaluated for their protective effects in hypoxia-induced myocardial injury model. Compounds 2-4, 6, and 10 exhibited anti-myocardial ischemia activities with ED50 values in the range of 75.77-127.22 µM.<br /> (Georg Thieme Verlag KG Stuttgart · New York.)
- Subjects :
- Carbohydrate Conformation
Magnetic Resonance Spectroscopy
Saponins chemistry
Saponins isolation & purification
Spectrometry, Mass, Electrospray Ionization
Triterpenes chemistry
Triterpenes isolation & purification
Clematis chemistry
Myocardial Ischemia drug therapy
Saponins therapeutic use
Triterpenes therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1439-0221
- Volume :
- 79
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Planta medica
- Publication Type :
- Academic Journal
- Accession number :
- 23670628
- Full Text :
- https://doi.org/10.1055/s-0032-1328541