Back to Search
Start Over
The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas.
- Source :
-
Journal of neuroimmunology [J Neuroimmunol] 2013 Jul 15; Vol. 260 (1-2), pp. 99-106. Date of Electronic Publication: 2013 May 09. - Publication Year :
- 2013
-
Abstract
- Inflammation is a component of glioma microenvironment. PTX3 is a component of the humoral arm of innate immunity and a candidate marker of inflammation. In the present study we assessed the expression of PTX3 in gliomas by immunohistochemistry. PTX3 expression differed across low and high-grade tumors based on histopathological diagnosis and clinical severity, positively correlating with tumor grade and severity. In a multivariate logistic regression model, only the PTX3 score was significantly associated with the presence of a high-grade tumor. Thus, PTX3 may represent a new marker of cancer-related inflammation and glioma malignancy.<br /> (Copyright © 2013 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Antigens, CD metabolism
Antigens, Differentiation, Myelomonocytic metabolism
Biomarkers, Tumor genetics
Biomarkers, Tumor metabolism
Brain Neoplasms metabolism
Brain Neoplasms pathology
C-Reactive Protein genetics
C-Reactive Protein metabolism
DNA Modification Methylases genetics
DNA Repair Enzymes genetics
Encephalitis metabolism
Encephalitis pathology
Female
Glioblastoma metabolism
Glioblastoma pathology
Humans
Logistic Models
Macrophages immunology
Male
Middle Aged
Multivariate Analysis
Neoplasm Grading
Oligodendroglioma metabolism
Oligodendroglioma pathology
Predictive Value of Tests
Prognosis
Serum Amyloid P-Component genetics
Serum Amyloid P-Component metabolism
Severity of Illness Index
Tumor Suppressor Proteins genetics
Brain Neoplasms immunology
C-Reactive Protein immunology
Encephalitis immunology
Glioblastoma immunology
Oligodendroglioma immunology
Serum Amyloid P-Component immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8421
- Volume :
- 260
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Journal of neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 23664694
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2013.04.009