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Mechanically tunable, self-adjuvanting nanoengineered polypeptide particles.
- Source :
-
Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2013 Jul 05; Vol. 25 (25), pp. 3468-72. Date of Electronic Publication: 2013 May 10. - Publication Year :
- 2013
-
Abstract
- DNA-loaded polypeptide particles are prepared via templated assembly of mesoporous silica for the delivery of adjuvants. The elasticity and cargo-loading capacity of the obtained particles can be tuned by the amount of cross-linker used to stabilize the polypeptide particles. The use of polypeptide particles as biocarriers provides a promising method for vaccine delivery.<br /> (Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Adjuvants, Immunologic chemistry
Base Sequence
CpG Islands
Dendritic Cells drug effects
Dendritic Cells immunology
Drug Carriers metabolism
Humans
Oligonucleotides chemistry
Oligonucleotides genetics
Oligonucleotides metabolism
Polyglutamic Acid chemistry
Adjuvants, Immunologic metabolism
Adjuvants, Immunologic pharmacology
Mechanical Phenomena
Nanotechnology
Peptides metabolism
Protein Engineering
Subjects
Details
- Language :
- English
- ISSN :
- 1521-4095
- Volume :
- 25
- Issue :
- 25
- Database :
- MEDLINE
- Journal :
- Advanced materials (Deerfield Beach, Fla.)
- Publication Type :
- Academic Journal
- Accession number :
- 23661596
- Full Text :
- https://doi.org/10.1002/adma.201300981