Parameterization of annealing kinetics in pharmaceutical glasses.

Authors :: Hodge IM
Source :: Journal of pharmaceutical sciences [J Pharm Sci] 2013 Jul; Vol. 102 (7), pp. 2235-40. Date of Electronic Publication: 2013 May 09.
Publication Year :: 2013
Abstract: Numerical simulations indicate that neglecting the canonical nonlinearity of glassy-state annealing kinetics in pharmaceutical (and other) glasses leads to good KWW fits to the dependence of enthalpy on annealing time, but with spurious KWW parameters that are affected by nonlinearity. A simplified treatment of nonlinearity that uses the Struik shift factor is found to be a useful approximation for these analyses, and can account for previously reported differences between linear and nonlinear KWW parameters (Kawakami K, Pikal MJ. 2005. J Pharm Sci 94:948-965).<br /> (Copyright © 2013 Wiley Periodicals, Inc.)