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Effects of aerobic exercise and drug therapy on blood pressure and antihypertensive drugs: a randomized controlled trial.
- Source :
-
African health sciences [Afr Health Sci] 2013 Mar; Vol. 13 (1), pp. 1-9. - Publication Year :
- 2013
-
Abstract
- Background: Although aerobic exercise has been shown to lower blood pressure (BP) in human beings, its additive BP-reducing effect on antihypertensive drug therapy seems to have been investigated in only laboratory animals.<br />Objectives: This study investigated the effects of aerobic dance combined with antihypertensive drugs on BP and number of antihypertensive drugs in individuals with hypertension.<br />Methods: This open label randomised-controlled trial involved new-diagnosed male and female individuals with mild-to-moderate essential hypertension after at least four weeks of treatment. They were randomly assigned to drug therapy (Normoretic: Hydrochlorothiazide + amiloride hydrochloride, and Amlodipine) (control: n=33) and aerobic dance combined with drug therapy (exercise: n=30) groups. Intervention in each group lasted 12 weeks. BP was measured at baseline and during and pos-intervention. Number of antihypertensive drugs was recorded post-intervention.<br />Results: There were significant reductions in SBP at some periods of the intervention in the exercise group (p=0.000 to 0.002) and control group (p=0.001 to 0.002), and significant difference in DBP at some periods of the intervention in exercise group (p=0.000 to 0.003) and control group (p=0.000 to 0.001). SBP (p=0.066) and DBP (p=0.100) did not differ between the two groups post-12-week intervention. The BP control rates were similar between the exercises (56.7%) and control (35.5%) groups (p=0.075). Similarly, between-group difference in the number of drugs was not significant (p=0.511).<br />Conclusion: This preliminary report demonstrates the tendency of aerobic dance to enhance BP control in individuals on two antihypertensive drugs without BP control.
- Subjects :
- Adult
Aged
Aged, 80 and over
Amiloride therapeutic use
Antihypertensive Agents pharmacology
Diuretics therapeutic use
Drug Combinations
Exercise
Female
Humans
Hydrochlorothiazide therapeutic use
Male
Middle Aged
Treatment Outcome
Amlodipine therapeutic use
Antihypertensive Agents therapeutic use
Blood Pressure drug effects
Exercise Therapy methods
Hypertension therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1729-0503
- Volume :
- 13
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- African health sciences
- Publication Type :
- Academic Journal
- Accession number :
- 23658561
- Full Text :
- https://doi.org/10.4314/ahs.v13i1.1