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HLA-B27-mediated protection in HIV and hepatitis C virus infection and pathogenesis in spondyloarthritis: two sides of the same coin?
- Source :
-
Current opinion in rheumatology [Curr Opin Rheumatol] 2013 Jul; Vol. 25 (4), pp. 426-33. - Publication Year :
- 2013
-
Abstract
- Purpose of Review: HLA-B27 is associated with low viral load and long-term nonprogression in HIV infection as well as spontaneous clearance of hepatitis C virus (HCV) infection. This review summarizes mechanisms that have been suggested to be involved in this protective effect of HLA-B27, and highlights possible lessons for the role of HLA-B27 in spondyloarthritis.<br />Recent Findings: Recent studies linked protection by HLA-B27 in HIV and HCV infection to virological mechanisms such as a complicated pathways of viral escape from immunodominant HLA-B27-restricted virus-specific CD8+ T-cell epitopes. In addition, several immunological mechanisms have been proposed, including CD8+ T-cell polyfunctionality and functional avidity, thymic selection of CD8+ T-cell precursors, specific T-cell receptor repertoires and clonotypes, efficient antigen processing, and evasion from regulatory T-cell-mediated suppression.<br />Summary: Multiple virological and immunological mechanisms have been suggested to contribute to HLA-B27-mediated protection in HIV and HCV infection. Some of these mechanisms may also be involved in HLA-B27-associated pathogenesis in spondyloarthritis.
- Subjects :
- CD8-Positive T-Lymphocytes immunology
Disease Progression
HIV Infections virology
HIV Long-Term Survivors
HLA-B27 Antigen genetics
Hepatitis C virology
Humans
Immunodominant Epitopes immunology
Spondylarthritis genetics
Viral Load immunology
HIV Infections immunology
HLA-B27 Antigen immunology
Hepatitis C immunology
Spondylarthritis immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1531-6963
- Volume :
- 25
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Current opinion in rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 23656712
- Full Text :
- https://doi.org/10.1097/BOR.0b013e328362018f