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Value of cardiac 320-multidetector computed tomography and cardiac magnetic resonance imaging for assessment of myocardial perfusion defects in patients with known chronic ischemic heart disease.
- Source :
-
The international journal of cardiovascular imaging [Int J Cardiovasc Imaging] 2013 Oct; Vol. 29 (7), pp. 1585-93. Date of Electronic Publication: 2013 May 08. - Publication Year :
- 2013
-
Abstract
- The challenge for therapies targeting perfusion abnormalities is to identify and evaluate the region of interest. The aim of this study was to compare rest and stress myocardial perfusion measured by cardiac multi-detector computed tomography (MDCT) and cardiac magnetic resonance (CMR) imaging in patients with invasive coronary angiography demonstrated occluded vessels. Twenty-four patients with refractory angina due to occluded coronary arteries underwent perfusion imaging obtained by 320-MDCT scanner and 1.5 T MR scanner. Rest and adenosine stress images were obtained and interpreted using the modified 17-segment American Heart Association model. For the qualitative analysis, each segment was graded according to the following scoring system: 0 = no defect, 1 = hypoperfusion transmural extent <1/3, 2 = 1/3-1/2, 3 = >1/2, and 4 = infarct stigmata. In the semiquantitative analysis the perfusion was either scored 0 (normal) or 1 (abnormal). The summed rest and stress scores were calculated. MDCT and CMR had a high probability to identify perfusion defects. An excellent correlation between MDCT and CMR summed rest (r = 0.916) and stress scores (r = 0.915) was found. The interobserver reproducibility was high for MDCT and CMR images. The qualitative and semiquantitative MDCT against CMR analysis of rest and stress images showed high concordance to detect perfusion defects per vascular territory and on a per myocardial segment basis. 320-MDCT and CMR perfusion imaging can be used clinically to identify myocardial perfusion defects and potentially evaluate the effect of therapy targeting perfusion abnormalities.
- Subjects :
- Adenosine
Aged
Aged, 80 and over
Angina Pectoris diagnostic imaging
Angina Pectoris physiopathology
Coronary Occlusion diagnostic imaging
Coronary Occlusion physiopathology
Female
Humans
Male
Middle Aged
Observer Variation
Predictive Value of Tests
Reproducibility of Results
Vasodilator Agents
Angina Pectoris diagnosis
Coronary Angiography
Coronary Circulation
Coronary Occlusion diagnosis
Magnetic Resonance Imaging, Cine
Multidetector Computed Tomography
Myocardial Perfusion Imaging methods
Subjects
Details
- Language :
- English
- ISSN :
- 1875-8312
- Volume :
- 29
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The international journal of cardiovascular imaging
- Publication Type :
- Academic Journal
- Accession number :
- 23653247
- Full Text :
- https://doi.org/10.1007/s10554-013-0234-6