Back to Search
Start Over
Value of melanocytic-associated immunohistochemical markers in the diagnosis of malignant melanoma: a review and update.
- Source :
-
Human pathology [Hum Pathol] 2014 Feb; Vol. 45 (2), pp. 191-205. Date of Electronic Publication: 2013 May 03. - Publication Year :
- 2014
-
Abstract
- Since the identification of S100 protein as an immunohistochemical marker that could be useful in the diagnosis of melanoma in the early 1980s, a large number of other melanocytic-associated markers that could potentially be used to assist in the differential diagnosis of these tumors have also been investigated. A great variation exists, however, among these markers, not only in their expression in some subtypes of melanoma, particularly desmoplastic melanoma, but also in their specificity because some of them can also be expressed in nonmelanocytic neoplasms, including various types of soft tissue tumors and carcinomas. This article reviews the information that is currently available on the practical value of some of the markers that have more often been recommended for assisting in the diagnosis of melanomas, including those that have only recently become available.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Subjects :
- CD146 Antigen analysis
Humans
Immunohistochemistry
Interferon Regulatory Factors immunology
MART-1 Antigen immunology
Melanoma immunology
Melanoma metabolism
Melanoma-Specific Antigens immunology
Microphthalmia-Associated Transcription Factor immunology
Monophenol Monooxygenase immunology
Nerve Tissue Proteins analysis
Nerve Tissue Proteins immunology
Receptor, Melanocortin, Type 1 analysis
Receptor, Melanocortin, Type 1 immunology
Receptors, Nerve Growth Factor analysis
Receptors, Nerve Growth Factor immunology
S100 Proteins immunology
SOXE Transcription Factors analysis
SOXE Transcription Factors immunology
Skin Neoplasms
Tetraspanin 30 analysis
Tetraspanin 30 immunology
gp100 Melanoma Antigen
Melanoma, Cutaneous Malignant
Antibodies, Monoclonal analysis
Biomarkers, Tumor analysis
Melanocytes immunology
Melanoma diagnosis
Melanoma-Specific Antigens analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8392
- Volume :
- 45
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Human pathology
- Publication Type :
- Academic Journal
- Accession number :
- 23648379
- Full Text :
- https://doi.org/10.1016/j.humpath.2013.02.007