Back to Search
Start Over
Locoregional recurrence in patients with HER2 positive breast cancer.
- Source :
-
Breast (Edinburgh, Scotland) [Breast] 2013 Oct; Vol. 22 (5), pp. 856-62. Date of Electronic Publication: 2013 May 01. - Publication Year :
- 2013
-
Abstract
- Literature shows that HER2/neu positive breast cancer cells are more sensitive to radiation-induced apoptosis by targeting the epidermal growth factor receptor family tyrosine kinase. We selected 466 patients with pT1-2 HER2/neu positive tumors who received adjuvant trastuzumab for primary invasive breast cancer. Patients were divided into three groups [Quadrantectomy followed by conventional radiotherapy vs Quadrantectomy followed by Intra-operative radiotherapy with electrons vs Mastectomy without radiotherapy]. After a median follow-up of 52 months, the 5-year cumulative incidence of locoregional recurrence (LRR) was 1.9%, 11.5% and 5.0% respectively (p < 0.01). At the multivariate analysis, extensive perivascular invasion, Luminal B HER2/Progesterone Receptor (PgR) negative status and Quadrantectomy followed by Intra-operative radiotherapy with electrons have significantly increased the risk of LRR. Our results suggest that HER2/neu positive breast cancer might have better outcomes when treated simultaneously with external radiotherapy and trastuzumab. Moreover, we underline the importance of PgR and further new stratification of risk among luminal subtypes.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Antibodies, Monoclonal, Humanized therapeutic use
Antineoplastic Agents therapeutic use
Breast Neoplasms chemistry
Carcinoma chemistry
Chemotherapy, Adjuvant
Female
Humans
Ki-67 Antigen analysis
Mastectomy, Segmental
Middle Aged
Radiotherapy, Adjuvant methods
Receptor, ErbB-2 analysis
Receptors, Progesterone analysis
Retrospective Studies
Trastuzumab
Young Adult
Breast Neoplasms therapy
Carcinoma therapy
Neoplasm Recurrence, Local chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1532-3080
- Volume :
- 22
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Breast (Edinburgh, Scotland)
- Publication Type :
- Academic Journal
- Accession number :
- 23642529
- Full Text :
- https://doi.org/10.1016/j.breast.2013.03.010