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The association of type 2 diabetes and insulin resistance/secretion with persistent organic pollutants in two First Nations communities in northern Ontario.
- Source :
-
Diabetes & metabolism [Diabetes Metab] 2013 Dec; Vol. 39 (6), pp. 497-504. Date of Electronic Publication: 2013 Apr 29. - Publication Year :
- 2013
-
Abstract
- Aims: Recent evidence suggests an association between persistent organic pollutants (POPs) and type 2 diabetes. In two First Nations communities where wild food is consumed by a large portion of the population, we compared pollutants in plasma between diabetic and non-diabetic individuals, and investigated the strength of association between pollutants and insulin resistance/secretion in non-diabetic individuals.<br />Methods: The study population consisted of 72 participants. Oral Glucose Tolerance Tests were used to assess diabetes status. Plasma was used to determine POP concentrations and mercury concentrations were determined from hair samples.<br />Results: Age-adjusted plasma concentrations of some pollutants were significantly higher in diabetic than in non-diabetic individuals. When taking into account age, adiposity levels, and smoking status, POP levels were not associated with insulin resistance nor with insulin secretion in non-diabetic individuals.<br />Conclusions: These findings confirm that POP concentrations in plasma may be higher in diabetic than in non-diabetic individuals. No association was however seen between POP concentrations and markers of insulin resistance/secretion in non-diabetic individuals.<br /> (Copyright © 2013 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Adult
Analysis of Variance
Causality
Female
Humans
Insulin metabolism
Insulin Secretion
Male
Mercury blood
Obesity ethnology
Ontario epidemiology
Pesticides blood
Sex Distribution
Diabetes Mellitus, Type 2 blood
Diabetes Mellitus, Type 2 ethnology
Environmental Monitoring statistics & numerical data
Environmental Pollutants blood
Food Contamination statistics & numerical data
Indians, North American statistics & numerical data
Insulin Resistance ethnology
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1780
- Volume :
- 39
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Diabetes & metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 23639570
- Full Text :
- https://doi.org/10.1016/j.diabet.2013.01.006