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Prime-boost interval matters: a randomized phase 1 study to identify the minimum interval necessary to observe the H5 DNA influenza vaccine priming effect.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2013 Aug 01; Vol. 208 (3), pp. 418-22. Date of Electronic Publication: 2013 Apr 30. - Publication Year :
- 2013
-
Abstract
- Background: H5 DNA priming was previously shown to improve the antibody response to influenza A(H5N1) monovalent inactivated vaccine (MIV) among individuals for whom there was a 24-week interval between prime and boost receipt. This study defines the shortest prime-boost interval associated with an improved response to MIV.<br />Methods: We administered H5 DNA followed by MIV at intervals of 4, 8, 12, 16, or 24 weeks and compared responses to that of 2 doses of MIV (prime-boost interval, 24 weeks).<br />Results: H5 DNA priming with an MIV boost ≥12 weeks later showed an improved response, with a positive hemagglutination inhibition (HAI) titer in 91% of recipients (geometric mean titer [GMT], 141-206), compared with 55%-70% of recipients with an H5 DNA and MIV prime-boost interval of ≤8 weeks (GMT, 51-70) and 44% with an MIV-MIV prime-boost interval of 24 weeks (GMT, 27).<br />Conclusion: H5 DNA priming enhances antibody responses after an MIV boost when the prime-boost interval is 12-24 weeks. Clinical Trials Registration. NCT01086657.
- Subjects :
- Adolescent
Adult
Antibodies, Viral blood
Female
Hemagglutination Inhibition Tests
Hemagglutinin Glycoproteins, Influenza Virus genetics
Humans
Male
Middle Aged
Time Factors
Vaccines, Inactivated administration & dosage
Vaccines, Inactivated immunology
Young Adult
Hemagglutinin Glycoproteins, Influenza Virus immunology
Immunization, Secondary methods
Influenza Vaccines administration & dosage
Influenza Vaccines immunology
Vaccines, DNA administration & dosage
Vaccines, DNA immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 208
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 23633407
- Full Text :
- https://doi.org/10.1093/infdis/jit180