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Sesquiterpenoids from the herb of Leonurus japonicus.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2013 Apr 29; Vol. 18 (5), pp. 5051-8. Date of Electronic Publication: 2013 Apr 29. - Publication Year :
- 2013
-
Abstract
- Two new sesquiterpenoids, (-)-(1S*,2S*,3R*)-3-ethoxycupar-5-ene-1,2-diol (1) and (-)-(1S*,4S*,9S*)-1,9-epoxybisabola-2,10-diene-4-ol (2), along with six known compounds 3-8, were isolated from the EtOH extract of the herb of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis. In the in vitro assays, compounds 7 and 8 showed obvious antibacterial activity against several bacteria strains, while compound 3 significantly inhibited abnormal increase of platelet aggregation induced by ADP.
- Subjects :
- Adenosine Diphosphate pharmacology
Animals
Blood Platelets cytology
Rats
Rats, Sprague-Dawley
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents isolation & purification
Anti-Bacterial Agents pharmacology
Bacteria growth & development
Blood Platelets metabolism
Leonurus chemistry
Plants, Medicinal chemistry
Platelet Aggregation drug effects
Sesquiterpenes chemistry
Sesquiterpenes isolation & purification
Sesquiterpenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 18
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 23629758
- Full Text :
- https://doi.org/10.3390/molecules18055051