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Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Jun 01; Vol. 23 (11), pp. 3385-8. Date of Electronic Publication: 2013 Mar 29. - Publication Year :
- 2013
-
Abstract
- The synthesis of new ribo and 2'-β-C-methyl ribo Janus type nucleosides J-AA, J-AG and J-AU is reported along with their ability to block HCV and HIV replication. Their toxicity was also assessed in Huh7, human lymphocytes, CEM and Vero cells.<br /> (Published by Elsevier Ltd.)
- Subjects :
- Animals
Cell Line
Chlorocebus aethiops
Enzyme Inhibitors chemistry
Enzyme Inhibitors pharmacology
Humans
Nucleosides chemical synthesis
Nucleosides pharmacology
Structure-Activity Relationship
Vero Cells
Viral Nonstructural Proteins metabolism
Virus Replication drug effects
Enzyme Inhibitors chemical synthesis
Hepacivirus enzymology
Nucleosides chemistry
Viral Nonstructural Proteins antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 23
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 23623492
- Full Text :
- https://doi.org/10.1016/j.bmcl.2013.03.077