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Optical coherence tomography in paediatric glaucoma: time domain versus spectral domain.
- Source :
-
The British journal of ophthalmology [Br J Ophthalmol] 2013 Jul; Vol. 97 (7), pp. 837-42. Date of Electronic Publication: 2013 Apr 25. - Publication Year :
- 2013
-
Abstract
- Background/aims: Spectral-domain (SD)- Optical Coherence Tomography (OCT) can track eye movements, has faster acquisition time and higher resolution than time-domain(TD)-OCT. The aim of the study was to assess the utility of SD-OCT in paediatric glaucoma and determine its agreement with TD-OCT.<br />Methods: Children who had SD-OCT(Spectralis, Heidelberg-Engineering,Germany) were retrospectively and prospectively identified from Duke paediatric glaucoma clinic. The peripapillary retinal nerve fibre layer (RNFL) and macular thickness and volume (MV) were compared amongst four groups: normal eyes, eyes with physiologic cupping (C:D >0.5 and <0.8, IOP <21), mild glaucomatous eyes (C:D <0.5, intra-ocular pressure (IOP) >21) and severe glaucoma (C:D>0.5, IOP>21). SD-OCT values were compared to TD-OCT(OCT-3, Carl-Zeiss-Meditec, Dublin, CA) values in a subset of subjects who had same day scans using both instruments. Children with neurologic disorders, refractive error >±5D, pseudophakia and prematurity were excluded.<br />Results: Included were 83 eyes of 83 children, mean age 11.9 ± 4.2 years. SD-OCT measurements of average RNFL thickness and MV differed among normals(n=24), physiologically cupped (n=31), mild (n=15) versus severe glaucoma (n=13): (RNFL:104 ± 9, 99 ± 6, 98 ± 9 vs 62 ± 18 µm, respectively, p<0.05; MV: 8.7 ± 0.3, 8.6 ± 0.3, 8.8 ± 0.4 vs 8.0 ± 0.6 mm³;, respectively, p<0.05). Same-day SD-OCT and TD-OCT measures in 53 eyes correlated linearly (RNFL r(2)=0.88; MVr(2)=0.58). SD-OCT measured lower RNFL and higher macular thickness than TD-OCT. Among eyes with severe glaucoma, 4 of 13 (30%) had unreliable TD-OCT but reliable SD-OCT.<br />Conclusions: SD-OCT was easier to obtain than TD-OCT in children. SD-OCT and TD-OCT measurements correlated, but values were not interchangeable.
- Subjects :
- Adolescent
Child
Child, Preschool
Female
Humans
Intraocular Pressure
Male
Ocular Hypertension diagnosis
Prospective Studies
Reproducibility of Results
Retrospective Studies
Tonometry, Ocular
Visual Fields physiology
Young Adult
Glaucoma diagnosis
Nerve Fibers pathology
Optic Disk pathology
Optic Nerve Diseases diagnosis
Retinal Ganglion Cells pathology
Tomography, Optical Coherence instrumentation
Subjects
Details
- Language :
- English
- ISSN :
- 1468-2079
- Volume :
- 97
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The British journal of ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 23620420
- Full Text :
- https://doi.org/10.1136/bjophthalmol-2012-302648