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A whole-grain-rich diet reduces urinary excretion of markers of protein catabolism and gut microbiota metabolism in healthy men after one week.

Authors :
Ross AB
Pere-Trépat E
Montoliu I
Martin FP
Collino S
Moco S
Godin JP
Cléroux M
Guy PA
Breton I
Bibiloni R
Thorimbert A
Tavazzi I
Tornier L
Bebuis A
Bruce SJ
Beaumont M
Fay LB
Kochhar S
Source :
The Journal of nutrition [J Nutr] 2013 Jun; Vol. 143 (6), pp. 766-73. Date of Electronic Publication: 2013 Apr 24.
Publication Year :
2013

Abstract

Epidemiological studies consistently find that diets rich in whole-grain (WG) cereals lead to decreased risk of disease compared with refined grain (RG)-based diets. Aside from a greater amount of fiber and micronutrients, possible mechanisms for why WGs may be beneficial for health remain speculative. In an exploratory, randomized, researcher-blinded, crossover trial, we measured metabolic profile differences between healthy participants eating a diet based on WGs compared with a diet based on RGs. Seventeen healthy adult participants (11 female, 6 male) consumed a controlled diet based on either WG-rich or RG-rich foods for 2 wk, followed by the other diet after a 5-wk washout period. Both diets were the same except for the use of WG (150 g/d) or RG foods. The metabolic profiles of plasma, urine, and fecal water were measured using (1)H-nuclear magnetic resonance spectroscopy and gas chromatography-mass spectrometry (plasma only). After 1 wk of intervention, the WG diet led to decreases in urinary excretion of metabolites related to protein catabolism (urea, methylguanadine), lipid (carnitine and acylcarnitines) and gut microbial (4-hydroxyphenylacetate, trimethylacetate, dimethylacetate) metabolism in men compared with the same time point during the RG intervention. There were no differences between the interventions after 2 wk. Urinary urea, carnitine, and acylcarnitine were lower at wk 1 of the WG intervention relative to the RG intervention in all participants. Fecal water short-chain fatty acids acetate and butyrate were relatively greater after the WG diet compared to the RG diet. Although based on a small population and for a short time period, these observations suggest that a WG diet may affect protein metabolism.

Details

Language :
English
ISSN :
1541-6100
Volume :
143
Issue :
6
Database :
MEDLINE
Journal :
The Journal of nutrition
Publication Type :
Academic Journal
Accession number :
23616503
Full Text :
https://doi.org/10.3945/jn.112.172197