The class III phosphatidylinositol 3-kinase PIK3C3/VPS34 regulates endocytosis and autophagosome-autolysosome formation in podocytes.

Authors :: Bechtel W
Helmstädter M
Balica J
Hartleben B
Schell C
Huber TB
Source :: Autophagy [Autophagy] 2013 Jul; Vol. 9 (7), pp. 1097-9. Date of Electronic Publication: 2013 Apr 15.
Publication Year :: 2013
Abstract: Phosphatidylinositol phosphates are key regulators of vesicle identity, formation and trafficking. In mammalian cells, the evolutionarily conserved class III PtdIns 3-kinase PIK3C3/VPS34 is part of a large multiprotein complex that catalyzes the localized phosphorylation of phosphatidylinositol to phosphatidylinositol-3-phosphate (PtdIns3P). We demonstrate that PIK3C3 has a key function in vesicular trafficking, endocytosis and autophagosome-autolysosome formation in the highly specialized glomerular podocytes.

Subjects :: Animals
Class III Phosphatidylinositol 3-Kinases deficiency
Drosophila melanogaster cytology
Humans
Mice
Models, Biological
Autophagy
Class III Phosphatidylinositol 3-Kinases metabolism
Endocytosis
Lysosomes metabolism
Phagosomes metabolism
Podocytes cytology
Podocytes enzymology

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