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The analog of Ginkgo biloba extract 761 is a protective factor of cognitive impairment induced by chronic fluorosis.
- Source :
-
Biological trace element research [Biol Trace Elem Res] 2013 Jun; Vol. 153 (1-3), pp. 229-36. Date of Electronic Publication: 2013 Apr 19. - Publication Year :
- 2013
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Abstract
- Ginkgo biloba extract EGb761 is widely used to treat patients with learning and memory impairment in Alzheimer's disease and Parkinson's disease in China. However, it is not yet clear whether the analog of EGb761 (EGb) has a protective effect on the learning and memory damage induced by chronic fluorosis. In this study, 30 Wistar rats were randomly divided into three groups: a control group, a sodium fluoride (NaF) + EGb group, and a NaF group. The rats were administered 0.5 ml water containing NaF (100 mg/l) and EGb (120 mg/kg) per day via gavage. After 3 months, the rats' capacity for learning and memory was tested using a Y-maze. Damage to hippocampal neurons was evaluated by histological examination of the CA3 area. Superoxide dismutase (SOD) activity and the levels of glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) were measured. Furthermore, the expression levels of Bcl-2 and Bax and the levels of cleaved Caspase3 in the hippocampus were evaluated by RT-PCR and Western blotting. The results showed that EGb could improve learning and memory abilities, enhance the activities of SOD and GSH-Px, attenuate the level of MDA, upregulate the ratio of Bcl-2/Bax, and downregulate the level of cleaved Caspase3.
- Subjects :
- Animals
Base Sequence
Blotting, Western
CA3 Region, Hippocampal drug effects
CA3 Region, Hippocampal enzymology
CA3 Region, Hippocampal metabolism
Chronic Disease
Cognition Disorders etiology
DNA Primers
Male
Malondialdehyde metabolism
Maze Learning
Rats
Rats, Wistar
Reverse Transcriptase Polymerase Chain Reaction
Cognition Disorders drug therapy
Fluorosis, Dental complications
Ginkgo biloba chemistry
Plant Extracts therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1559-0720
- Volume :
- 153
- Issue :
- 1-3
- Database :
- MEDLINE
- Journal :
- Biological trace element research
- Publication Type :
- Academic Journal
- Accession number :
- 23605048
- Full Text :
- https://doi.org/10.1007/s12011-013-9645-4