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Anti-oxidant vitamin E prevents accumulation of imatinib-resistant BCR-ABL1 kinase mutations in CML-CP xenografts in NSG mice.
- Source :
-
Leukemia [Leukemia] 2013 Nov; Vol. 27 (11), pp. 2253-4. Date of Electronic Publication: 2013 Apr 22. - Publication Year :
- 2013
- Subjects :
- Animals
Antineoplastic Agents adverse effects
Humans
Imatinib Mesylate
Interleukin Receptor Common gamma Subunit physiology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy
Leukemia, Myelogenous, Chronic, BCR-ABL Positive genetics
Mice
Mice, Inbred NOD
Mice, SCID
Antioxidants therapeutic use
Benzamides adverse effects
Drug Resistance, Neoplasm drug effects
Fusion Proteins, bcr-abl genetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive prevention & control
Mutation genetics
Piperazines adverse effects
Pyrimidines adverse effects
Vitamin E therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1476-5551
- Volume :
- 27
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Leukemia
- Publication Type :
- Report
- Accession number :
- 23604228
- Full Text :
- https://doi.org/10.1038/leu.2013.123