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A validated scoring system to identify long-term survivors after radiotherapy for metastatic spinal cord compression.
- Source :
-
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] [Strahlenther Onkol] 2013 Jun; Vol. 189 (6), pp. 462-6. Date of Electronic Publication: 2013 Apr 20. - Publication Year :
- 2013
-
Abstract
- Purpose: This study aimed to develop and validate a scoring system to identify long-term survivors after conventional radiotherapy (RT) for metastatic spinal cord compression (MSCC).<br />Patients and Methods: Data from 1,125 patients who had received long-course RT for MSCC were included in this study. Of these patients, 344 survived for over 12 months and 781 died within a year following RT. Based on differences between the distributions of patient characteristics in the two groups, a scoring system was developed. Scores ranged from 0 to 18 points and 15 points was selected as the cutoff for identifying long-term survivors. Data from the 1,125 long-course RT patients (test group) were compared to data from 773 patients receiving short-course RT (validation group).<br />Results: A score of ≥ 15 points was associated with a 94 % proportion of long-term survivors. The 15-point cutoff resulted in a specificity of 98 % and a positive predictive value of 94 % for identification of long-term surviving patients. The proportions of long-term survivors for each scoring point in the validation group were very similar to those in the test group.<br />Conclusion: This new scoring system enabled identification of long-term survivors after RT for MSCC with very high specificity and positive predictive value. The score proved to be valid and reproducible.
- Subjects :
- Aged
Disease Progression
Female
Germany
Humans
Long-Term Care
Male
Middle Aged
Neurologic Examination
Particle Accelerators
Radiotherapy Planning, Computer-Assisted
Spinal Cord Compression mortality
Spinal Cord Compression radiotherapy
Spinal Neoplasms mortality
Spinal Neoplasms radiotherapy
Spinal Neoplasms secondary
Survivors
Subjects
Details
- Language :
- English
- ISSN :
- 1439-099X
- Volume :
- 189
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
- Publication Type :
- Academic Journal
- Accession number :
- 23604188
- Full Text :
- https://doi.org/10.1007/s00066-013-0342-1