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Allelic polymorphisms of human platelets-specific alloantigens in South Tunisian population.
- Source :
-
Hematology (Amsterdam, Netherlands) [Hematology] 2013 Nov; Vol. 18 (6), pp. 365-9. Date of Electronic Publication: 2013 Apr 18. - Publication Year :
- 2013
-
Abstract
- Objectives: Human platelet-specific alloantigens (HPA) are polymorphic epitopes which vary among ethnic groups.<br />Background: In Tunisia, HPA frequencies were determined in North and centre; however, the pattern of HPA in South Tunisian population is not been studied yet. The aim of this work was to determine allelic frequencies of HPA-1, -3, and -5 systems in south Tunisian population, in order to estimate the risk of anti-platelet allo-immunization and to create a register of HPA-typed blood donors.<br />Methods: Our study concerned 212 unrelated healthy, regular blood donors from southern Tunisia. Allelic polymorphisms of each system were determined using a polymerase chain reaction with sequence-specific primers.<br />Results: Genotype frequencies a/a, a/b, and b/b were, respectively, 0.670, 0.288, and 0.042 for HPA-1 system, 0.430, 0.462, and 0.108 for HPA-3 system, and 0.750, 0.241, and 0.009 for HPA-5 system. The allele frequencies were 0.814 and 0.186 for HPA-1a and -1b alleles; 0.660 and 0.340 for HPA-3a and -3b alleles and 0.870, and 0.130 for HPA-5a and -5b alleles.<br />Discussion: The reported frequencies are more similar to those of Caucasians than those of north Tunisian population.
Details
- Language :
- English
- ISSN :
- 1607-8454
- Volume :
- 18
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Hematology (Amsterdam, Netherlands)
- Publication Type :
- Academic Journal
- Accession number :
- 23601927
- Full Text :
- https://doi.org/10.1179/1607845413Y.0000000087