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Prognostic role of myocardial performance index on long-term survival after heart transplantation: a prospective study.
- Source :
-
Echocardiography (Mount Kisco, N.Y.) [Echocardiography] 2013 Oct; Vol. 30 (9), pp. 1033-41. Date of Electronic Publication: 2013 Apr 19. - Publication Year :
- 2013
-
Abstract
- The survival rate of heart transplant patients is increasing, underlying the need for accurate predictors of adverse events during clinical follow-up. Myocardial performance index (MPI) is a Doppler-derived index of combined systolic and diastolic function: we assessed the prognostic role of MPI in survival of patients >1 year after heart transplantation (HT). A total of 152 consecutive HT patients referred to our institution were enrolled in this prospective study. Primary endpoints were cardiac death and a composite of major adverse cardiac events (MACE). During follow-up (69 ± 22 months), 68 (44.7%) patients had an adverse event and 20 (13.15%) patients died. Patients with MACE during follow-up showed lower EF (57.3 ± 9.3 vs. 63 ± 6.1; P < 0.001) and higher MPI (0.45 ± 0.19 vs. 0.31 ± 0.13; P < 0.001) at enrolment. MPI and EF were independently related to MACE (OR = 2.2; 95% confidence interval [CI] = 1.01-5.1; and OR = 6.6; 95% CI = 3.5-11.2, respectively) and showed strong diagnostic power (MPI: receiver operating characteristic [ROC] area = 79%, with 79% sensitivity and 81% specificity; EF: ROC area = 77%, with 54% sensitivity and 91% specificity) in the subsequent year. Patients with EF > 50% and MPI < 0.45 at enrolment showed 75% event-free survival 5 years after HT. In HT patients, MPI combined with EF was an accurate means of predicting long-term adverse events.<br /> (© 2013, Wiley Periodicals, Inc.)
- Subjects :
- Death, Sudden, Cardiac prevention & control
Echocardiography methods
Female
Humans
Incidence
Italy epidemiology
Male
Middle Aged
Prognosis
Prospective Studies
Reproducibility of Results
Risk Assessment methods
Sensitivity and Specificity
Survival Analysis
Death, Sudden, Cardiac epidemiology
Echocardiography statistics & numerical data
Heart Failure mortality
Heart Failure surgery
Heart Transplantation mortality
Postoperative Complications mortality
Survivors statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1540-8175
- Volume :
- 30
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Echocardiography (Mount Kisco, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 23600857
- Full Text :
- https://doi.org/10.1111/echo.12220