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Stress peptide PACAP stimulates and stabilizes neonatal breathing through distinct mechanisms.
- Source :
-
Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2013 Jul 01; Vol. 187 (3), pp. 217-23. Date of Electronic Publication: 2013 Apr 15. - Publication Year :
- 2013
-
Abstract
- Pituitary adenylate cyclase-activating peptide (PACAP) is an important mediator of the stress response and is crucial in maintaining breathing in neonates. Here we investigate the role of exogenously applied PACAP in neonatal breathing using the neonatal rat in situ working heart-brainstem preparation. A 1-min bolus of 250 nM PACAP-38 caused an increased in respiratory frequency that was rapid and transient, but had no effect on neural tidal volume or neural minute ventilation. Denervation of the carotid body abolished this effect. PACAP had a persistent effect on breathing stability in both carotid body-intact and -denervated preparations, as shown by decreases in respiratory variability 5 min following application. These data suggest that PACAP released during stress acts via carotid body dependent and independent mechanisms to stimulate and stabilize breathing. These mechanisms may account for PACAP's critical role in defending neonatal breathing against environmental stress.<br /> (Copyright © 2013 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Animals, Newborn
Brain Stem physiology
Carotid Body drug effects
Denervation
Female
In Vitro Techniques
Male
Pulmonary Ventilation drug effects
Rats
Rats, Sprague-Dawley
Reaction Time drug effects
Tidal Volume drug effects
Time Factors
Brain Stem drug effects
Carotid Body physiology
Pituitary Adenylate Cyclase-Activating Polypeptide pharmacology
Respiration drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1519
- Volume :
- 187
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Respiratory physiology & neurobiology
- Publication Type :
- Academic Journal
- Accession number :
- 23597836
- Full Text :
- https://doi.org/10.1016/j.resp.2013.04.009