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Iron and cancer: more ore to be mined.
- Source :
-
Nature reviews. Cancer [Nat Rev Cancer] 2013 May; Vol. 13 (5), pp. 342-55. Date of Electronic Publication: 2013 Apr 18. - Publication Year :
- 2013
-
Abstract
- Iron is an essential nutrient that facilitates cell proliferation and growth. However, iron also has the capacity to engage in redox cycling and free radical formation. Therefore, iron can contribute to both tumour initiation and tumour growth; recent work has also shown that iron has a role in the tumour microenvironment and in metastasis. Pathways of iron acquisition, efflux, storage and regulation are all perturbed in cancer, suggesting that reprogramming of iron metabolism is a central aspect of tumour cell survival. Signalling through hypoxia-inducible factor (HIF) and WNT pathways may contribute to altered iron metabolism in cancer. Targeting iron metabolic pathways may provide new tools for cancer prognosis and therapy.
- Subjects :
- Animals
Antineoplastic Agents pharmacology
Cell Cycle
Cell Hypoxia
DNA metabolism
Humans
Iron Chelating Agents pharmacology
Iron-Binding Proteins metabolism
Metabolic Networks and Pathways
Neoplasms drug therapy
Neoplasms pathology
Signal Transduction
Tumor Microenvironment
Iron metabolism
Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1474-1768
- Volume :
- 13
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Nature reviews. Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 23594855
- Full Text :
- https://doi.org/10.1038/nrc3495