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Disulfide/thiol switches in thiosemicarbazone ligands for redox-directed iron chelation.
- Source :
-
Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2013 Jun 14; Vol. 42 (22), pp. 7846-9. Date of Electronic Publication: 2013 Apr 16. - Publication Year :
- 2013
-
Abstract
- A disulfide bond is incorporated in the scaffold of thiosemicarbazone iron chelators as a reduction/activation switch. Following reduction, thiol-containing ligands stabilize iron ions in their trivalent oxidation state. The antiproliferative activity of the new chelating systems is assessed in human cancer cell lines and in normal tissue.
Details
- Language :
- English
- ISSN :
- 1477-9234
- Volume :
- 42
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Dalton transactions (Cambridge, England : 2003)
- Publication Type :
- Academic Journal
- Accession number :
- 23591852
- Full Text :
- https://doi.org/10.1039/c3dt50824b