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The role of patent ductus arteriosus and its treatments in the development of bronchopulmonary dysplasia.
- Source :
-
Seminars in perinatology [Semin Perinatol] 2013 Apr; Vol. 37 (2), pp. 102-7. - Publication Year :
- 2013
-
Abstract
- A persistent left-to-right shunt through a patent ductus arteriosus (PDA) increases the rate of hydrostatic fluid filtration into the lung's interstitium, impairs pulmonary mechanics, and prolongs the need for mechanical ventilation. In preclinical trials, pharmacologic PDA closure leads to improved alveolarization and minimizes the impaired postnatal alveolar development that is the pathologic hallmark of the "new bronchopulmonary dysplasia (BPD)". Although early pharmacologic closure of the PDA decreases the incidence of pulmonary hemorrhage, intraventricular hemorrhage, and the need for PDA ligation, there is little evidence from controlled, clinical trials to support or refute a causal role for the PDA in the development of BPD. However, evidence from epidemiologic, preclinical, and randomized controlled clinical trials demonstrate that early ductus ligation is an independent risk factor for the development of BPD and may directly contribute to the neonatal morbidities it is trying to prevent.<br /> (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Disease Models, Animal
Ductus Arteriosus, Patent complications
Ductus Arteriosus, Patent surgery
Humans
Infant, Newborn
Infant, Premature
Pulmonary Circulation
Respiration, Artificial adverse effects
Bronchopulmonary Dysplasia etiology
Cyclooxygenase Inhibitors therapeutic use
Ductus Arteriosus, Patent drug therapy
Ibuprofen therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1558-075X
- Volume :
- 37
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Seminars in perinatology
- Publication Type :
- Academic Journal
- Accession number :
- 23582964
- Full Text :
- https://doi.org/10.1053/j.semperi.2013.01.006