Back to Search
Start Over
Optical coherence tomography does not support optic nerve involvement in amyotrophic lateral sclerosis.
- Source :
-
European journal of neurology [Eur J Neurol] 2013 Aug; Vol. 20 (8), pp. 1170-6. Date of Electronic Publication: 2013 Apr 14. - Publication Year :
- 2013
-
Abstract
- Background and Purpose: In recent years a possible non-motor involvement of the nervous system in amyotrophic lateral sclerosis (ALS) has come into the focus of research and has been investigated by numerous techniques. Optical coherence tomography (OCT) - with its potential to reveal neuroaxonal retinal damage - may be an appropriate tool to investigate whether the anterior visual pathway is involved. Our aim was to determine whether OCT-based measures of retinal nerve fiber layer, ganglion cell layer, inner nuclear layer and outer nuclear layer thickness are abnormal in ALS, or correlated with disease severity.<br />Methods: Seventy-six ALS patients (144 eyes) and 54 healthy controls (108 eyes; HCs) were examined with OCT, including automated intraretinal macular segmentation. ALS disease severity was determined with the Amyotrophic Lateral Sclerosis Functional Rating Scale - Revised.<br />Results: There was no significant difference between ALS patients and HCs in any of the examined OCT measures. Moreover, OCT parameters showed no correlation with clinical measures of disease severity.<br />Conclusions: These findings indicate that involvement of the anterior visual pathway is not one of the non-motor manifestations of ALS.<br /> (© 2013 The Author(s) European Journal of Neurology © 2013 EFNS.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Cohort Studies
Disease Progression
Female
Humans
Male
Middle Aged
Retinal Ganglion Cells pathology
Retinal Neurons pathology
Retinal Photoreceptor Cell Inner Segment pathology
Retinal Photoreceptor Cell Outer Segment pathology
Amyotrophic Lateral Sclerosis pathology
Optic Nerve pathology
Tomography, Optical Coherence methods
Subjects
Details
- Language :
- English
- ISSN :
- 1468-1331
- Volume :
- 20
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- European journal of neurology
- Publication Type :
- Academic Journal
- Accession number :
- 23582075
- Full Text :
- https://doi.org/10.1111/ene.12146