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Bisphenol A and phthalates and endometriosis: the Endometriosis: Natural History, Diagnosis and Outcomes Study.

Authors :
Buck Louis GM
Peterson CM
Chen Z
Croughan M
Sundaram R
Stanford J
Varner MW
Kennedy A
Giudice L
Fujimoto VY
Sun L
Wang L
Guo Y
Kannan K
Source :
Fertility and sterility [Fertil Steril] 2013 Jul; Vol. 100 (1), pp. 162-9.e1-2. Date of Electronic Publication: 2013 Apr 08.
Publication Year :
2013

Abstract

Objective: To explore the relation between bisphenol A and 14 phthalate metabolites and endometriosis.<br />Design: Matched cohort design.<br />Setting: Fourteen clinical centers.<br />Patient(s): The operative cohort comprised 495 women undergoing laparoscopy/laparotomy, whereas the population cohort comprised 131 women matched on age and residence.<br />Intervention(s): None.<br />Main Outcome Measure(s): Surgically visualized or pelvic magnetic resonance imaging diagnosed endometriosis in the two cohorts, respectively.<br />Result(s): Odds ratios (OR) and 95% confidence intervals (CIs) were estimated using logistic regression adjusting for age, body mass index, and creatinine. In the population cohort, six phthalate metabolites-mono-n-butyl phthalate, mono-[(2-carboxymethyl) hexyl] phthalate, mono (2-ethyl-5-carboxyphentyl) phthalate, mono (2-ethylhexyl) phthalate, mono (2-ethyl-5-hydroxyhexyl) phthalate, and mono (2-ethyl-5-oxohexyl) phthalate-were significantly associated with an approximately twofold increase in the odds of an endometriosis diagnosis. Two phthalates were associated with endometriosis in the operative cohort when restricting to visualized and histologic endometriosis (monooctyl phthalate; OR 1.38; 95% CI 1.10-1.72) or when restricting comparison women to those with a postoperative diagnosis of a normal pelvis [mono (2-ethylhexyl) phthalate; OR 1.35; 95% CI 1.03-1.78].<br />Conclusion(s): Select phthalates were associated with higher odds of an endometriosis diagnosis for women with magnetic resonance imaging-diagnosed endometriosis. The lack of consistency of findings across cohorts underscores the impact of methodology on findings.<br /> (Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1556-5653
Volume :
100
Issue :
1
Database :
MEDLINE
Journal :
Fertility and sterility
Publication Type :
Academic Journal
Accession number :
23579005
Full Text :
https://doi.org/10.1016/j.fertnstert.2013.03.026