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Defining the signals that constitute the nephron progenitor niche.
- Source :
-
Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2013 May; Vol. 24 (6), pp. 873-6. Date of Electronic Publication: 2013 Apr 11. - Publication Year :
- 2013
-
Abstract
- For decades we have known that reciprocal inductive interactions between the embryonic ureteric bud and the metanephric mesenchyme are the basis for kidney development. Signals from the mesenchyme promote the branching of the bud, whereas signals from the bud regulate the survival, proliferation, and differentiation of nephron progenitors. Due to the complex nature of the bud-derived signals, progress in identifying these factors has been slow. However, in the last several years, tremendous advances have been made in identifying specific roles for various secreted proteins in nephron progenitor cell development. Here, we briefly review the roles for Fgfs and Wnts in induction of the nephron progenitors.
- Subjects :
- Animals
Fibroblast Growth Factors metabolism
Humans
Mesoderm cytology
Mesoderm embryology
Mesoderm metabolism
Nephrons cytology
Nephrons metabolism
Stem Cells cytology
Ureter cytology
Ureter metabolism
Wnt Proteins metabolism
Nephrons embryology
Signal Transduction physiology
Stem Cell Niche physiology
Stem Cells metabolism
Ureter embryology
Subjects
Details
- Language :
- English
- ISSN :
- 1533-3450
- Volume :
- 24
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of the American Society of Nephrology : JASN
- Publication Type :
- Academic Journal
- Accession number :
- 23578945
- Full Text :
- https://doi.org/10.1681/ASN.2012090931