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Stereotactic ablative body radiation therapy for octogenarians with non-small cell lung cancer.
- Source :
-
International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2013 Jun 01; Vol. 86 (2), pp. 257-63. Date of Electronic Publication: 2013 Apr 06. - Publication Year :
- 2013
-
Abstract
- Purpose: To retrospectively investigate treatment outcomes of stereotactic ablative body radiation therapy (SABR) for octogenarians with non-small cell lung cancer (NSCLC).<br />Methods and Materials: Between 2005 and 2012, 109 patients aged ≥80 years with T1-2N0M0 NSCLC were treated with SABR: 47 patients had histology-unproven lung cancer; 62 patients had pathologically proven NSCLC. The prescribed doses were either 50 Gy/5 fractions for peripheral tumors or 40 Gy/5 fractions for centrally located tumors. The treatment outcomes, toxicities, and the correlating factors for overall survival (OS) were evaluated.<br />Results: The median follow-up duration after SABR was 24.2 (range, 3.0-64.6) months. Only limited toxicities were observed, except for 1 grade 5 radiation pneumonitis. The 3-year local, regional, and distant metastasis-free survival rates were 82.3%, 90.1%, and 76.8%, respectively. The OS and lung cancer-specific survival rates were 53.7% and 70.8%, respectively. Multivariate analysis revealed that medically inoperable, low body mass index, high T stage, and high C-reactive protein were the predictors for short OS. The OS for the operable octogenarians was significantly better than that for inoperable (P<.01).<br />Conclusions: Stereotactic ablative body radiation therapy for octogenarians was feasible, with excellent OS. Multivariate analysis revealed that operability was one of the predictors for OS. For medically operable octogenarians with early-stage NSCLC, SABR should be prospectively compared with resection.<br /> (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Subjects :
- Aged, 80 and over
C-Reactive Protein metabolism
Carcinoma, Non-Small-Cell Lung mortality
Carcinoma, Non-Small-Cell Lung pathology
Dose Fractionation, Radiation
Feasibility Studies
Female
Follow-Up Studies
Humans
Lung Neoplasms pathology
Male
Multivariate Analysis
Neoplasm Proteins metabolism
Neoplasm Staging
Retrospective Studies
Survival Rate
Treatment Outcome
Carcinoma, Non-Small-Cell Lung surgery
Lung Neoplasms surgery
Radiosurgery methods
Subjects
Details
- Language :
- English
- ISSN :
- 1879-355X
- Volume :
- 86
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of radiation oncology, biology, physics
- Publication Type :
- Academic Journal
- Accession number :
- 23570699
- Full Text :
- https://doi.org/10.1016/j.ijrobp.2013.01.006