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Discovery and characterization of protein-modifying natural products by MALDI mass spectrometry reveal potent SIRT1 and p300 inhibitors.
- Source :
-
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2013 May 03; Vol. 52 (19), pp. 5171-4. Date of Electronic Publication: 2013 Apr 08. - Publication Year :
- 2013
- Subjects :
- Acetylation
Cells, Cultured
E1A-Associated p300 Protein metabolism
Heterocyclic Compounds, 4 or More Rings pharmacology
Humans
Molecular Structure
Monocytes cytology
Monocytes drug effects
Monocytes metabolism
Optical Imaging
Resveratrol
Sirtuin 1 metabolism
Stilbenes pharmacology
Biological Products pharmacology
E1A-Associated p300 Protein antagonists & inhibitors
Enzyme Inhibitors pharmacology
Peptide Fragments metabolism
Sirtuin 1 antagonists & inhibitors
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Subjects
Details
- Language :
- English
- ISSN :
- 1521-3773
- Volume :
- 52
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- Angewandte Chemie (International ed. in English)
- Publication Type :
- Academic Journal
- Accession number :
- 23568553
- Full Text :
- https://doi.org/10.1002/anie.201207325