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Obesity affects short-term folate pharmacokinetics in women of childbearing age.
- Source :
-
International journal of obesity (2005) [Int J Obes (Lond)] 2013 Dec; Vol. 37 (12), pp. 1608-10. Date of Electronic Publication: 2013 Apr 09. - Publication Year :
- 2013
-
Abstract
- Maternal folate status and body mass index (BMI) are independent risk factors for neural tube defects (NTD). Population-based studies have identified an inverse association between serum folate and BMI, after adjusting for intake. The objective of this intervention study was to compare the relationship between BMI and the short-term pharmacokinetic response to an oral dose of folic acid. Healthy obese (BMI 30.0 kg m(-2); n=16) and normal-weight (BMI 18.5-24.9 kg m(-2); n=16) women of childbearing age (18-35 years) were administered a single oral dose of folic acid (400 μg). Blood samples were collected over a 10-h period to evaluate the serum folate response. Fasting baseline serum folate was lower in the obese group (P=0.005); in contrast, red blood cell folate was higher (P=0.05). Area-under-the-curve for the absorption phase (0-3 h) and peak serum folate concentrations were lower in obese versus normal-weight women (P<0.005). Overall serum folate response (0-10 h) was lower in obese versus normal-weight women (repeated-measures ANOVA, P=0.001). Data suggest body distribution of folate is significantly affected by obesity, and, should pregnancy occur, may reduce the amount of folate available to the developing embryo. These findings provide additional support for a BMI-adjusted folic acid intake recommendation for NTD risk reduction.
- Subjects :
- Adolescent
Adult
Body Mass Index
Female
Folic Acid administration & dosage
Folic Acid blood
Humans
Neural Tube Defects etiology
Obesity complications
Pregnancy
Risk Factors
Dietary Supplements
Folic Acid pharmacokinetics
Neural Tube Defects prevention & control
Obesity blood
Prenatal Care methods
Subjects
Details
- Language :
- English
- ISSN :
- 1476-5497
- Volume :
- 37
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- International journal of obesity (2005)
- Publication Type :
- Academic Journal
- Accession number :
- 23567925
- Full Text :
- https://doi.org/10.1038/ijo.2013.41