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Autotransporter secretion: varying on a theme.
- Source :
-
Research in microbiology [Res Microbiol] 2013 Jul-Aug; Vol. 164 (6), pp. 562-82. Date of Electronic Publication: 2013 Apr 06. - Publication Year :
- 2013
-
Abstract
- Autotransporters are widely distributed among Gram-negative bacteria. They can have a large variety of functions and many of them have a role in virulence. They are synthesized as large precursors with an N-terminal signal sequence that mediates transport across the inner membrane via the Sec machinery and a translocator domain that mediates the transport of the connected passenger domain across the outer membrane to the bacterial cell surface. Like integral outer membrane proteins, the translocator domain folds in a β-barrel structure and requires the Bam machinery for its insertion into the outer membrane. After transport across the outer membrane, the passenger may stay connected via the translocator domain to the bacterial cell surface or it is proteolytically released into the extracellular milieu. Based on the size of the translocator domain and its position relative to the passenger in the precursor, autotransporters are divided into four sub-categories. We review here the current knowledge of the biogenesis, structure and function of various autotransporters.<br /> (Copyright © 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Bacterial Proteins chemistry
Bacterial Proteins genetics
Cell Membrane chemistry
Cell Membrane genetics
Cell Membrane metabolism
Gram-Negative Bacteria chemistry
Gram-Negative Bacteria genetics
Membrane Transport Proteins chemistry
Membrane Transport Proteins genetics
Protein Structure, Tertiary
Protein Transport
Bacterial Proteins metabolism
Bacterial Secretion Systems
Gram-Negative Bacteria metabolism
Membrane Transport Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1769-7123
- Volume :
- 164
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Research in microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 23567321
- Full Text :
- https://doi.org/10.1016/j.resmic.2013.03.010