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Premixed injectable calcium phosphate cement with excellent suspension stability.
- Source :
-
Journal of materials science. Materials in medicine [J Mater Sci Mater Med] 2013 Jul; Vol. 24 (7), pp. 1627-37. Date of Electronic Publication: 2013 Apr 06. - Publication Year :
- 2013
-
Abstract
- Premixed injectable calcium phosphate cement (p-ICPC) pastes have advantages over aqueous injectable calcium phosphate cement (a-ICPC) because p-ICPC remain stable during storage and harden only after placement into the defect. This paper focused on the suspension stability of p-ICPC paste by using fumed silica as a stabilizing agent and propylene glycol (PEG) as a continuous phase. Multiple light scanning techniques were first applied to evaluate the suspension stability. The results indicated that fumed silica effectively enhanced the suspension stability of p-ICPC pastes. The stabilizing effect of fumed silica results from the network structure formed in PEG because of its thixotropy. The p-ICPC could be eventually hydrated to form hydroxyapatite under aqueous circumstances by the unique replacement between water and PEG. p-ICPC (1) not only possesses proper thixotropy and compressive strength but has good injectability as well. p-ICPC (1) was cytocompatible and had no adverse effect on the attachment and proliferation of MG-63 cells in vitro. These observations may have applicability to the development of other nonaqueous injectable biomaterials for non-immediate filling and long-term storage.
- Subjects :
- Animals
Body Fluids physiology
Bone Cements pharmacokinetics
Calcium Phosphates pharmacokinetics
Cell Proliferation drug effects
Cells, Cultured
Chemical Precipitation
Compressive Strength
Drug Stability
Injections
Materials Testing methods
Mice
Osteoblasts drug effects
Osteoblasts physiology
Rheology
Suspensions
Viscoelastic Substances chemistry
Bone Cements chemistry
Calcium Phosphates administration & dosage
Calcium Phosphates chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1573-4838
- Volume :
- 24
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of materials science. Materials in medicine
- Publication Type :
- Academic Journal
- Accession number :
- 23563980
- Full Text :
- https://doi.org/10.1007/s10856-013-4920-7