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Innovative solutions to novel drug development in mental health.
- Source :
-
Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2013 Dec; Vol. 37 (10 Pt 1), pp. 2438-44. Date of Electronic Publication: 2013 Apr 03. - Publication Year :
- 2013
-
Abstract
- There are many new advances in neuroscience and mental health which should lead to a greater understanding of the neurobiological dysfunction in neuropsychiatric disorders and new developments for early, effective treatments. To do this, a biomarker approach combining genetic, neuroimaging, cognitive and other biological measures is needed. The aim of this article is to highlight novel approaches for pharmacological and non-pharmacological treatment development. This article suggests approaches that can be taken in the future including novel mechanisms with preliminary clinical validation to provide a toolbox for mechanistic studies and also examples of translation and back-translation. The review also emphasizes the need for clinician-scientists to be trained in a novel way in order to equip them with the conceptual and experimental techniques required, and emphasizes the need for private-public partnership and pre-competitive knowledge exchange. This should lead the way for important new holistic treatment developments to improve cognition, functional outcome and well-being of people with neuropsychiatric disorders.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1873-7528
- Volume :
- 37
- Issue :
- 10 Pt 1
- Database :
- MEDLINE
- Journal :
- Neuroscience and biobehavioral reviews
- Publication Type :
- Academic Journal
- Accession number :
- 23563062
- Full Text :
- https://doi.org/10.1016/j.neubiorev.2013.03.022