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Role of C-reactive protein in determining microvascular function in patients with non-ST-segment elevation acute coronary syndrome undergoing percutaneous coronary intervention.
- Source :
-
The American journal of cardiology [Am J Cardiol] 2013 Jun 15; Vol. 111 (12), pp. 1734-8. Date of Electronic Publication: 2013 Apr 01. - Publication Year :
- 2013
-
Abstract
- The extent of coronary microvascular dysfunction might be related, not only to patient characteristics and procedural factors, but also to the inflammatory status. The aim of the present study was to examine a possible association between inflammation, as reflected by the serum C-reactive protein (CRP) levels, and the extent of baseline and post-percutaneous coronary intervention (PCI) coronary microvascular dysfunction in patients with non-ST-segment elevation acute coronary syndrome undergoing PCI. A total of 42 patients undergoing PCI for non-ST-segment elevation acute coronary syndrome were enrolled. Coronary microvascular resistance (MR) was determined in the territory of culprit artery using a Doppler probe- and a pressure sensor-equipped guidewire both before (taking the collateral blood into account) and after PCI. The periprocedural changes in MR were calculated. The CRP levels at admission were correlated with the pre-PCI MR (r = 0.498, p = 0.001), post-PCI MR (r = 0.429, p = 0.005), and periprocedural changes in MR (r = 0.785, p <0.001). On multivariate regression analysis, the only predictor of the pre-PCI (β = 0.531, p = 0.002) and post-PCI (β = 0.471, p = 0.012) MR was the serum CRP concentration. Likewise, the periprocedural changes in MR was predicted by the serum CRP levels (β = 0.677, p = 0.001) and the presence of angiographic thrombus (β = -0.275, p = 0.02). In conclusion, these results have shown that the CRP level is related to increased coronary MR in the territory of the culprit lesion. This suggests that inflammatory processes might play a role in microvascular impairment in patients with non-ST-segment elevation acute coronary syndrome.<br /> (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Subjects :
- Acute Coronary Syndrome diagnosis
Acute Coronary Syndrome physiopathology
Aged
Biomarkers metabolism
Coronary Angiography
Coronary Vessels diagnostic imaging
Female
Humans
Male
Middle Aged
Predictive Value of Tests
Sensitivity and Specificity
Treatment Outcome
Acute Coronary Syndrome blood
Acute Coronary Syndrome therapy
Angioplasty, Balloon, Coronary
C-Reactive Protein metabolism
Coronary Vessels physiopathology
Heart Conduction System physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1913
- Volume :
- 111
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The American journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 23558042
- Full Text :
- https://doi.org/10.1016/j.amjcard.2013.02.029