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Relation between transient or persistent acute kidney injury and long-term mortality in patients with myocardial infarction.
- Source :
-
The American journal of cardiology [Am J Cardiol] 2013 Jul 01; Vol. 112 (1), pp. 41-5. Date of Electronic Publication: 2013 Apr 01. - Publication Year :
- 2013
-
Abstract
- Limited information is available regarding the impact of acute kidney injury (AKI) during hospitalization on clinical outcomes after myocardial infarction (MI), and the effect of transient kidney injury (KI) on long-term mortality has not been validated. We retrospectively analyzed 2,289 patients diagnosed with MI. AKI patients were classified into a transient KI group and a persistent KI group based on serum creatinine levels at discharge. The end point of the study was 3-year mortality after MI. We included 2,110 patients of whom 237 patients (11%) developed AKI during hospitalization. Of these 237 patients, 154 (65%) had transient KI, and 83 (35%) had persistent KI. Multivariate analysis showed that age, left ventricular ejection fraction, estimated glomerular filtration rate on admission, and Killip class were significantly associated with developing AKI during hospitalization. The adjusted hazard ratios for 3-year mortality were 1.71 (95% confidence interval: 1.08-2.70) for AKI patients with transient KI and 2.21 (95% confidence interval: 1.34-3.64) for AKI patients with persistent KI, compared with no AKI. In conclusion, AKI was associated with an increased risk of death for patients who experienced MIs and survived during hospitalization. Although renal function had completely recovered in many AKI patients at discharge, these transient KI patients are also at a great risk of death after MI.<br /> (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Subjects :
- Acute Kidney Injury diagnosis
Aged
Analysis of Variance
Chi-Square Distribution
Comorbidity
Female
Follow-Up Studies
Humans
Logistic Models
Male
Middle Aged
Myocardial Infarction diagnosis
Prognosis
Proportional Hazards Models
Republic of Korea epidemiology
Retrospective Studies
Risk Factors
Survival Rate
Acute Kidney Injury mortality
Myocardial Infarction mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1913
- Volume :
- 112
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The American journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 23558040
- Full Text :
- https://doi.org/10.1016/j.amjcard.2013.02.051