Analytical evaluation of GeneXpert CT/NG, the first genetic point-of-care assay for simultaneous detection of Neisseria gonorrhoeae and Chlamydia trachomatis.

Authors :: Tabrizi SN
Unemo M
Golparian D
Twin J
Limnios AE
Lahra M
Guy R
Source :: Journal of clinical microbiology [J Clin Microbiol] 2013 Jun; Vol. 51 (6), pp. 1945-7. Date of Electronic Publication: 2013 Apr 03.
Publication Year :: 2013
Abstract: GeneXpert CT/NG was evaluated with 372 characterized bacterial strains. Sensitivity of 10 genome copies/reaction was obtained for both agents. Four Neisseria mucosa and two Neisseria subflava isolates were positive for one of two gonococcal targets; however, the assay flagged all as negative. The assay was analytically highly sensitive and specific.

Subjects :: Chlamydia trachomatis classification
Chlamydia trachomatis genetics
Gonorrhea microbiology
Humans
Lymphogranuloma Venereum microbiology
Male
Neisseria gonorrhoeae classification
Neisseria gonorrhoeae genetics
Sensitivity and Specificity
Bacteriological Techniques methods
Chlamydia trachomatis isolation & purification
Gonorrhea diagnosis
Lymphogranuloma Venereum diagnosis
Molecular Diagnostic Techniques methods
Neisseria gonorrhoeae isolation & purification
Point-of-Care Systems

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